摘要 :
Background: There is a critical need to increase the racial/ethnic diversity of prostate cancer researchers. The goal of the Training Program is to provide research training activities to 12 students over a 3-year period from thre...
展开
Background: There is a critical need to increase the racial/ethnic diversity of prostate cancer researchers. The goal of the Training Program is to provide research training activities to 12 students over a 3-year period from three Historically Black Colleges and Universities (HBCUs) in South Carolina: Claflin University, South Carolina State University, and Voorhees College. The three aims of the Training Program are: Aim 1.) To provide training in the basics of research design and methods to 4 Student Fellows each year from the three HBCUs; Aim 2.) To immerse 4 Student Fellows per year in prostate cancer research; Aim 3.) To implement a unique dual-level research mentoring strategy for the students. Results: During the current reporting period, 4 Student Fellows were identified, recruited to participate in the program, and admitted to the DOD South Carolina Collaborative Undergraduate HBCU Student Summer Training Program. The Student Fellows were matched with Research Mentors at MUSC, with whom they conducted research in the summer of 2014. Each Student Fellow prepared a scientific paper, gave a scientific presentation at the end of the summer program, and completed an 8-week Princeton Review Graduate Record Examination Test Preparation Course. In the summer of 2014, additional students at SCSU participated in summer program lectures via video conference. Conclusions: State-of-the art comprehensive prostate cancer research education and training opportunities were provided to 4 Student Fellows from HBCUs in South Carolina. Each Student Fellow prepared a scientific paper and gave at least 1 scientific presentation. Six Student Fellows, two of whom were supported by leveraged funds, gave scientific presentations. A cadre of scientists who are well-prepared to conduct research spanning the continuum from basic science to clinical science to population-based research was developed.
收起
摘要 :
Proopiomelanocortin (POMC) is post-translationally processed to alpha-MSH, beta-endorphin, and a variety of other peptides, not only in the pituitary and brain, but in peripheral tissues as well. Beta-Endorphin and its immediate p...
展开
Proopiomelanocortin (POMC) is post-translationally processed to alpha-MSH, beta-endorphin, and a variety of other peptides, not only in the pituitary and brain, but in peripheral tissues as well. Beta-Endorphin and its immediate precursor beta-lipotropin (beta-LPH) have recently been identified in cardiac tissue suggesting that the POMC gene is expressed in heart, although neither the cellular localization nor the post-translational processing of cardiac POMC peptides has been fully characterized. The localization of beta-endorphin, as well as other opioid peptides, in cardiac tissue is consistent with extensive evidence that opiates produce direct effects on cardiac function, reducing cardiac output, coronary pressure, and heart rate. ACTH, alpha-MSH, and related ACTH fragments also exhibit potent, albeit opposing, cardio-regulatory activities, increasing rate and contractility, although their biosynthesis in cardiac tissue has not, as yet, been demonstrated. In the present study, we further characterized POMC processing in rat heart and also showed, using in situ hybridization, that POMC mRNA is localized within cardiac ventricular muscle cells.
收起
